Depression
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Determining the “IMPACT” of therapeutics for depression requires an adaptive trial design
A large proportion of adolescents suffering from moderate-to-severe major depression respond to psychological and pharmacological therapy, and the range of effective treatment modalities is increasing. Now, Ian Goodyer and Paul Wilkinson have compiled a Practitioner Review that compares the various treatment options available and assesses their effectiveness for adolescents affected by major depressive episodes.
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The trajectories of depressive symptoms expressed in early childhood differ between boys and girls
A study by Diana Whalen and colleagues at Washington University has used latent class analysis (LCA) to identify and define the trajectories of latent classes of depressive symptoms in early childhood.
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Genetic factors influence the relationship between the home environment and onset of depressive symptom
Clinical depression is prevalent in adolescence, but how depression emerges and the nature of the early risk factors is unknown. Insight has now come from a study performed by researchers at King’s College London.
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Offspring of mothers with depression show asymmetric frontal brain activity
These findings highlight the importance of a longitudinal study design in delineating the role of FA in depression.
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Depression is highly prevalent but under-reported in children with ADHD
Researchers at Cardiff University have investigated whether the symptoms of depression observed in patients with attention-deficit/hyperactivity disorder (ADHD) differ from those reported in the general population.
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Accelerated cortical thinning correlates with early signs of depression
The brain undergoes structural changes as it develops over childhood, but whether abnormal structural changes are associated with emerging depressive symptoms in adolescence is unknown. Now, a longitudinal study that enrolled 205 participants aged 8-25 years without signs of depression has used magnetic resonance imaging (MRI) to monitor these brain changes over adolescence.
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Clinical characteristics of adolescents referred for treatment of depressive disorders
Low mood and depression often emerge during adolescence and are associated with long-term difficulties including increased risk of developing other mental health disorders, educational underachievement, low income/unemployment, and risk of suicidal behaviour.
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Rumination affects mother–infant interactions
New research now shows that a ruminative state can affect the quality of sensitive maternal behaviours.
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mHealth ineffective for depression prevention
A universal cognitive behavioural therapy (CBT)-based mobile messaging programme (MEMO CBT) designed to prevent teenage onset depression provides no clinical benefit, according to results of a double-blind, randomised, placebo-controlled trial.
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Patient-centred practitioners prioritise PROMs
Clinicians who use therapeutic approaches that focus on patients’ perceptions, such as CBT, may be more likely to seek patient feedback.
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